TYPE: Colombia. Antioquia: Municipio de Yarumal, Vereda Tobón, Finca Guasimal, 2080 m. 25 Julio 2022. Sebastian Vieira et al. #382 (holotype: JAUM). Diagnosis: Epidendrum pembertonii is similar to E. brenesii Schltr. (Schlechter 1923) but easily distinguished by having two, elliptic (vs. 3–5, oblong) larger leaves (5.2–6.0 × 2.5–2.7 vs. 2–8 × 1.3–2.5 cm), longest inflorescence (7.2 vs. 2–4 cm), tepals greenish yellow with a brown tinge (vs. light green with purple tinge to deep purple), red lip with yellow to red calli (vs. purple tinge to deep purple lip with yellow-greenish calli), greenish yellow column (vs. green), the dorsal sepal narrowly obovate, 5-veined (vs. obovate-elliptic, 3-veined), the lateral sepals obliquely elliptic, 5-veined (vs. obovate-elliptic, 3-veined), the lip smooth, apex apiculate, (vs. velutinous, short setose, apex sometimes slightly 4-lobed) and the longer column (9–10 vs. 7–8 mm), straight, apex arching upwards (vs. arching downwards). Epiphytic, sympodial, erect to pendulous herb 78 cm tall, new stems produced from a sub-apical internode of previous stem. Roots fleshy, from base of primary stem. Stems 8–13 × 0.3–0.5 cm, cane-like, terete, erect to pendulous when weight in old plants makes them hang from the roots, simple. Leaves 2, aggregate towards the apex of the stem, spreading, alternate; sheaths 0.32–0.65 × 0.3–0.5 cm, tubular, striated, reddish-brown; blades 5.2–6.0 × 2.5–2.7 cm, elliptic, obtuse, coriaceous, green, concolor. Spathe lacking. Inflorescence 7.2 cm long, apical, from the mature stem, racemose, arcuate; peduncle 2.2 × 0.43 cm, laterally compressed, green; rachis 5 cm long, arching-nutant. Floral bracts 5–6 mm long, much shorter than ovary, decreasing in size towards apex of the rachis, triangular, acute, embracing. Flowers ca. 18, opening in succession, until most open at the same time, resupinate, greenish yellow tinged with brown, lip red with calli yellow to red, column greenish yellow, slightly tinged reddish brown, anther yellow; fragrance none detected. Ovary 12–15 × 2.2–2.8 mm, slightly inflated behind the perianth, terete, furrowed, somewhat arcuate. Sepals free, fleshy, 5-veined, margins entire; dorsal sepal 13.5 × 6.0 mm, spreading, narrowly obovate, sub-rounded, minutely apiculate; lateral sepals 13.1 × 7.5 mm, partly spreading, obliquely elliptic, obtuse, apiculate. Petals 13.5 × 4.2 mm, free, spreading, oblanceolate, apex obtuse, 3-veined, margin entire. Lip 9–12 × 15.2–17.0 mm, united to column, fleshy, convex, smooth, wider than long, reniform, base callose, calli globose, slightly separate, disc with a thick, low rib running at the apex, reaching apical sinus of lip. Column 9–10 mm long, somewhat thick towards the apex, truncate, straight, apex arching upwards. Clinandrium-hood reduced, margin entire. Anther 1.9 × 2.3 mm, sub-globose, apex minutely apiculate, apical surface minutely papillose, 4-celled. Pollinia 0.87 × 0.66 mm, ovoid; caudicles granulose, shorter than pollinia; viscarium semi-liquid. Rostellum apical, slit. Lateral lobes of stigma about half length of stigmatic cavity. Cuniculus shallow, slightly penetrating ovary, narrow, smooth. Capsule not seen.